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Soon after Marc Wilson gets his second dose of coronavirus vaccine, he plans to resume one of his pre-pandemic joys: swimming laps with his friends. But most other activities — including volunteering at a food pantry and homeless shelter — will be off-limits until the outbreak is curbed and scientists know more about the threat of emerging variants.

“I can definitely broaden the things I do, but I still have to be quite cautious,” said Wilson, 70, a retired accountant in Norman, Okla., who has diabetes and other health problems. “When your doctor tells you, ‘If you get COVID, you’re dead,’ that gets your attention real good.”