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Andrew Markert respects the coronavirus. It has messed with his livelihood, a D.C. pub called Beuchert’s Saloon, forcing him to close, move outdoors and adjust in countless other ways.

But the time has arrived for him to move forward and stick to his plans, come what may in the next round of the pandemic. And he’s betting there are a lot of people like him.

Fatigued, frustrated and frazzled by five surges over two years, some parts of the U.S. population have decided to simply live with the coronavirus and move on. And with a triple-shot of vaccine on board — or protection acquired from prior infection — alongside case numbers falling precipitously, polls show their numbers are increasing.

Some municipalities and schools are shedding mask requirements. Elected officials no longer even talk about conquering the virus, as President Biden did just seven months ago, in the short-lived glow of the vaccine rollout. A bipartisan group of governors told Biden last week at the White House it is time to “move away from the pandemic,” in the words of Arkansas Republican Gov. Asa Hutchinson.